Abstract
Background Recent evidence suggests that leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) may play an important role in down-regulating immune activities upon collagen binding [1], and its defective expression or dysfunction is clinically associated with some autoimmune diseases [2-5], cancer [6-8] and viral infection [9-12]. The human genome encodes the counterpart to LAIR-1, soluble protein LAIR-2 [13], which also binds collagen and can interfere with LAIR-1/collagen interactions [14]. However, LAIR-2 has no homologue in mouse or rat [13]. To clarify the extrapolative credibility of a murine model to human disease, we compared LAIR-1 genetic pathways in internal organs of the two species.
Highlights
Recent evidence suggests that leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) may play an important role in down-regulating immune activities upon collagen binding [1], and its defective expression or dysfunction is clinically associated with some autoimmune diseases [2,3,4,5], cancer [6,7,8] and viral infection [9,10,11,12]
Significant variation in LAIR-1 genetic pathways was found in mouse vs human internal organs The top 50 mouse genes by LAIR-1’s Pearson correlation were employed to search for the same genes in corresponding human tissue throughout relevant databases
The network node of LAIR-1 has a more robust connection for mouse than for human, and no common genes except for LAIR-1 were shared by liver, lung and brain in mice or humans
Summary
Recent evidence suggests that leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) may play an important role in down-regulating immune activities upon collagen binding [1], and its defective expression or dysfunction is clinically associated with some autoimmune diseases [2,3,4,5], cancer [6,7,8] and viral infection [9,10,11,12]. The human genome encodes the counterpart to LAIR-1, soluble protein LAIR-2 [13], which binds collagen and can interfere with LAIR-1/collagen interactions [14]. LAIR-2 has no homologue in mouse or rat [13]. To clarify the extrapolative credibility of a murine model to human disease, we compared LAIR-1 genetic pathways in internal organs of the two species
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