Abstract
Statins have been recommended for use in atherosclerotic cardio-cerebrovascular disease (CCVD). The purpose of this study was to investigate the efficacy of five different types of statin in the secondary prevention of CCVD in patients. This study retrospectively designed and analyzed data from the National Health Insurance Service-National Health in Korea. Participants aged 40 to 69 years were categorized into five statin groups (atorvastatin, rosuvastatin, pitavastatin, simvastatin, and pravastatin). The primary composite outcome was defined as recurrence of CCVD or all causes of death. Cox proportional hazard regression models were adopted after stepwise adjustments for confounders to investigate the difference in efficacy among the different statins. Of the 755 final participants, 48 patients experienced primary composite outcomes. After adjustments, the hazard ratios (95% confidence intervals) for primary composite outcomes of atorvastatin, pitavastatin, and rosuvastatin groups were 0.956 (0.456–2.005), 1.347 (0.354–5.116), and 0.943 (0.317–2.803), respectively, when compared with the simvastatin group. There were no significant differences between the statins in efficacy for preventing recurrence of CCVD events and/or death in CCVD patients.
Highlights
According to the World Health Organization fact sheet from 2017, atherosclerotic cardiovascular disease (ASCVD) is the number one cause of death worldwide
Total cholesterol levels were increased in pravastatin group and decreased in the rosuvastatin group
This study shows that there was no significant difference in preventing the recurrence of cardio-cerebrovascular disease (CCVD) and/or death among five different types of statin in CCVD patients
Summary
According to the World Health Organization fact sheet from 2017, atherosclerotic cardiovascular disease (ASCVD) is the number one cause of death worldwide. Approximately 17 million people died from ASCVD in 2016, accounting for 31% of all global deaths. Of these deaths, 85% were reported to be due to a heart attack and/or stroke [1]. In Korea, the socioeconomic burden of cardio-cerebrovascular disease (CCVD) is rapidly increasing.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.