Comparing anaesthetic effects of intrathecal 2- Chloroprocaine with or without fentanyl in ambulatory surgeries- A prospective and randomized control study

Abstract

1% 2-Chloroprocaine could have been an ideal local anaesthetic for ambulatory procedures but it has been neglected in past years and even after re introduction with its preservative and antioxidant free form. To compare the anaesthetic effect of intrathecal 2-Chloroprocaine with or without fentanyl in patients undergoing short duration lower abdominal and lower limb surgeries regarding hemodynamic parameters, mean duration of block, time to ambulation and side effects.Anesthesia Department at Narayana Multispeciality Hospital, Jaipur.Randomised, Comparative, Single Centre StudyA total of 120 patients,18-70 years, weight>50 kg and ASA grade I- II underwent elective lower abdominal and lower limb surgeries with expected duration <60 minutes were randomly allocated in two groups of 60 each to receive either 40mg 2- Chloroprocaine with saline or 25 µg fentanyl. Chi-Square and Unpaired Student T- Test (p<0.05). Spinal anesthesia was successful for all patients. Onset time of sensory and motor block, time to achieve peak block height and complete motor block was statistically insignificant (p<0.05). Time to complete sensory recovery was 105.87mins in fentanyl group and 69.17mins in saline group and time to compete motor recovery 80.13 mins in fentanyl group and 64.80 mins in saline group (p<0.001). Transient neurological symptoms were not found. 2-Chloroprocaine spinal anesthesia provides rapid onset, giving it a promising profile for ambulatory surgery. Addition of fentanyl lengthens regression to S2 and with minimal increase of motor block duration.