Abstract
1. 1. The efficiency of the contribution of hexoses to basal- and stimulated-glycogenesis, when studied in cultured 18 day-old rat foetal hepatocytes in the presence of glucose, was as follows: galactose > glucose > fructose. 2. 2. Glucose deprivation had opposite effects on the contributions of [ 14C]galactose (decreased) and [ 14C]fructose (increased) to glycogenesis, which occurred independently of insulin and were reversed by glucose concentrations as low as 30–100 μM. 3. 3. The stimulation of glycogenesis by insulin measured with [ 14C]glucose (3.2-fold) was superior to that obtained with either [ 14C]galactose or [ 14C]fructose (2.7-fold in both cases), which revealed a specific beneficial effect of insulin on glucose contribution.
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