COMPARED EFFICACY OF INTRA-ARTICULAR INJECTION OF METHYLPREDNISOLONE AND TRIAMCINOLONE.

Abdul Fettah Buyuk,Hanifi Ucpunar,Ismet Yalkin Camurcu,Eray Kilinc,Adnan Kara,Savas Camur

doi:10.1590/1413-785220172505172581

Abstract

ABSTRACTObjective:To compare the effect of two different corticosteroid types in bilateral and symmetrical knee osteoarthritis (OA). Methods:One hundred and twenty-six patients received injections of methylprednisolone acetate (MP) in one knee and triamcinolone hexacetonide (TH) in the contralateral knee. Patients were evaluated before injection and 2, 4, 8, 12, and 24 weeks after. Results:Mean patient age was 68.5±9 years. Mean BMI was 26.3±2.6 kg/m2. At first admission, mean VAS score was 7.7±1.3 for the right side and 7.5±1.5 for the left side, and mean WOMAC score was 67.6±14.4. After bilateral intra-articular injection, VAS scores for both knees and WOMAC scores decreased significantly when initial scores were compared with 2, 4, 8, 12, and 24 weeks after injection (p<0.05). A statistically significant change was seen over time when VAS and WOMAC scores for 2, 4, 8, 12, and 24 weeks post-injection were compared to each other (p<0.05). No significant difference was seen between knee sides (p>0.05). Conclusion:MP and TH have similar efficacy in relieving pain and improving function. The efficacy of intra-articular corticosteroid injection peaks 2 weeks after injection and the effect continues until the 24th week. Level of Evidence II, Comparative Prospective Study.

Highlights

Osteoarthritis of the knee is a major cause of pain and disability in older adults.[1]
A statistically significant change was seen over time when Visual Analog Scale (VAS) and WOMAC scores for 2, 4, 8, 12, and 24 weeks post-injection were compared to each other (p
We compared the medications by injecting methylprednisolone acetate (MP) in one knee and triamcinolone hexacetonide (TH) in the contralateral knee of the same patient

Summary

Introduction

Osteoarthritis of the knee is a major cause of pain and disability in older adults.[1] Pain control is one of the main goals in treating knee OA.[2] Management of this disease begins with conservative treatment such as physical therapy, exercise, weight loss, and medications; surgical intervention can be indicated for patients with advanced OA.[3] Intra-articular corticosteroid injections (IACI) are frequently used and recommended by the American College of Rheumatology as part of conservative therapy for knee OA.[4] The clinical benefits of IACI have been evaluated in several studies.[5,6,7] Some studies have raised concerns about progression of cartilage destruction, but others have shown that corticosteroid injections can reduce this progression.[8,9]

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Results

Discussion

Conclusion