Comparative study to evaluate the efficacy of treatment with platelet rich plasma and nonsteroidal anti-inflammatory drugs in gonarthrosis grade I-II

Abstract

Background: Worldwide, the incidence of degenerative diseases has increased, mainly gonarthrosis. The World Health Organization estimates that 40% of the population over 70 years of age has gonarthrosis, which may increase in the following decade,1 generating 10%-25% of consultations.2 Treatment with intra-articular Platelet Rich Plasma is an effective therapy.3 Methodology: A cross-sectional, prospective, quasi-experimental, non- randomized study was carried out comparing the evolution of the symptoms of grade I and II gonarthrosis in 140 patients, half treated with non-steroidal anti-inflammatory drugs (NSAIDs) and the other half treated with Platelet Rich Plasma (PRP), at the Specialty Clinic N.3, Cuauhtémoc Health Jurisdiction, 2020. Descriptive statistics were analyzed by calculating the mean and standard deviation, inferential statistics through Chi-square. Results: The most affected age group was from 60 to 69 years old with 43.5%, with a female sex prevailing with 33.5%. Most patients were overweight and obese with 39% and 53% respectively. Pain improved in 92% of patients treated with PRP and in 25.7% of patients treated with NSAIDs. The functional capacity of the knee recovered in 97% of the patients treated with PRP and in 35.7% of those treated with NSAIDs. Conclusions: treatment of grade I and II gonarthrosis with intra-articular PRP is more effective than treatment with NSAIDs.