Abstract
In order to critically evaluate the potential of dual cyclodextrin (CD) systems in CE, enantioseparation of the neutral chiral analyte glutethimide (GT) was performed using: (a) charged CDs; (b) combinations of charged and neutral CDs (dual CD systems), and (c) CD-modified micellar electrokinetic chromatography (CD-MECK). The results of this comparative study indicate that properly designed dual CD systems may in certain cases represent a valuable alternative to CD-MEKC and electrokinetic chromatography involving charged CDs for enantioseparation of neutral analytes.
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