Abstract
Purpose To evaluate the effects of prednisolone against sodium diclofenac both with ciprofloxacin compared to artificial tears on the symptoms and signs of acute viral conjunctivitis.Methods Study included 37 patients diagnosed with acute conjunctivitis and distributed by three groups: A (1% prednisolone acetate + ciprofloxacin (0.3%); B (Sodium diclofenac (0.1%) + ciprofloxacin (0.3%) and C (artificial tears + ciprofloxacin (0.3%). Patients received medication 6/6 hours daily. Signs and symptoms (e.g. lacrimation, burning, photophobia, etc.) were scored at baseline and on the first, third, fifth and seventh days and in the end of treatment using a standardized questionnaire and slit lamp anterior segment examination.Results All three groups demonstrated an improvement in the signs and symptoms of conjunctivitis in their follow-up visits. There was no significant difference in symptom and sign scores between Group A and B and B and C in the study visits ( p >0.05). However, the comparison between groups A and C showed a clinical trend (p=0.05) on third evaluation suggesting better clinical action using the corticosteroids.Conclusion The prednisolone acetate was not superior to the use of sodium diclofenac or artificial tears in relieving the signs and symptoms of viral conjunctivitis.
Highlights
70% of patients with acute conjunctivitis present to their primary care provider or an urgent care center rather than to an ophthalmologist[1]
The objective of this study was to evaluate the effects of the administration of prednisolone against sodium diclofenac both associated with ciprofloxacin compared to artificial tears on the symptoms and signs of acute viral conjunctivitis
Group A (n=16) received prednisolone (1%) plus ciprofloxacin (0.3%) demonstrated a trend in improvement of the symptoms when compared to group C (n=16) that received artificial tears plus ciprofloxacin (0.3%) in third evaluation (p=0.055); no statistical difference was observed between A and B or between B and C groups in the 1st, 2nd 3rd, 4th evaluation and in the last assessment respectively (Table 2)
Summary
70% of patients with acute conjunctivitis present to their primary care provider or an urgent care center rather than to an ophthalmologist[1]. Conjunctivitis is a common complaint in primary care, affecting all ages and socioeconomic classes affecting 6 million people annually in the United States[2,3]. Infectious conjunctivitis can have several etiologic factors, such as bacterial, viral, chlamydial, fungal, and parasitic. Non-infectious conjunctivitis includes allergens, toxicities, and irritants[4]. Common viral agents include adenovirus, herpes simplex, herpes zoster, and enterovirus. Allergic conjunctivitis encompasses seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis (VKC), atopic keratoconjunctivitis (AKC), and giant papillary conjunctivitis[4]
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