COMPARATIVE STUDY ON THE EFFICACY OF MOMETASONE AND FLUTICASONE NASAL SPRAYS FOR TREATMENT OF ALLERGIC RHINITIS

Mahshid Sadat Mirmoezzi,Mohammad Shurideh Yazdi,Omid Gholami

doi:10.22159/ijpps.2017v9i3.15958

Mahshid Sadat Mirmoezzi, Mohammad Shurideh Yazdi + Show 1 more

Open Access

https://doi.org/10.22159/ijpps.2017v9i3.15958

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Abstract

Objective: Allergic rhinitis is the most prevalent of allergic diseases in the world. Nasal corticosteroids are the most applicable drugs for the treatment of allergic rhinitis. In this study, we compared the efficacy of fluticasone propionate (FP) and mometasone furoate (MF) nasal sprays in the treatment of allergic rhinitis based on total nasal symptom score (TNSS) questionnaire.Methods: For this study, 75 allergic rhinitis patients based on skin prick test and inclusion criteria were randomly assigned to two groups: FP and MF groups. FP group received 200 µg dose of FP nasal spray (1 spray/nostril) daily and the MF group received 100 mg dose of MF nasal spray (1 spray/nostril) daily for 8 w. The effects of the two agents were compared based on TNSS questionnaire in 0, 4 and 8 w after the beginning of the treatment.Results: Results showed that patients in both groups exhibited significant improvement in their TNSS (P Value<0.001). A detailed TNSS analysis showed MF to be more effective for relieving all symptoms than FP. The most difference is in decreasing postnasal discharge (PND) symptom. However, the difference for relieving all symptoms is not significant (P value>0.05).Conclusion: In conclusion, FP and MF are significantly effective in relieving of allergic rhinitis symptoms. Even though, the difference between the two is not significant for 8 w therapy.

Highlights

Allergic rhinitis represents a global health problem that affects 10 to 20% of the population [1]
A total of 75 patients were enrolled in this study, with 36 patients assigned to an fluticasone propionate (FP) group and 33 patients assigned to an mometasone furoate (MF) group
We found MF sprays to be more effective than FP sprays for relieving nasal symptoms, as evidenced by the differences in total nasal symptom score (TNSS) between the two groups

Summary

Introduction

Allergic rhinitis represents a global health problem that affects 10 to 20% of the population [1]. Allergic rhinitis is a type I hypersensitivity reaction to exogenous substances like a plant or animal allergens. In this type of reaction, the cutaneous, mucosal-cutaneous or anaphylactic reaction occurs immediately or several minutes after exposure. Allergic rhinitis treatment includes allergen avoidance, pharmacotherapy, and immunotherapy. Intranasal corticosteroids are recommended as first-line therapy for patients with moderate-tosevere Allergic Rhinitis, especially when nasal congestion is a major component of symptoms [4]. To compare the efficacy and safety profile of different available Intranasal corticosteroids for the treatment of Allergic Rhinitis, it is important to understand the difference in chemical structures, their pharmacokinetic and pharmacodynamics properties [4]

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Discussion

Conclusion