Comparative Study on the Efficacy of Losartan and Amlodipine in Reducing Microalbuminuria in Patients with Primary Hypertension, a Randomized open Label Parallel Group Study

Abstract

Majority of the cardiovascular and renal diseases has been associated with Hypertension Primary hypertension also called as essential or idiopathic hypertension tends to be familial and the prevalence increases with age. Microalbuminuria has been correlated with microvascular damage in hypertension patients.To Compare the Efficacy of Losartan and Amlodipine in reducing microalbuminuria in patients with primary hypertension.An open labeled parellel group cross sectioned study was conducted in Sree Balaji medical college and hospital, Department of General Medicine Chrompet during the period of March 2015 to December 2015. In our research study suggested that there are major differences between Angiotensin receptor blockers and calcium chaneel blockers in reducing microalbuminuria in essential hypertension. After 6-month of losartan treatment, the reduction in urine albumin level is statistically highly significant (p<0.01) 71.17±66.04**. compared with baseline101.95±94.70. After 6 months of Amlodipine treatment group resulted in statistically not significant (p>0.05) in urine albumin excretion level 99.85±96.35 compared with baseline 101.11±95.28 in essential hypertensive patients .Hence this study shows that losartan after administration for 6 months ,conferred significant advantages over amlodipine in terms of reduction of urinary albumin levels levels in hypertension patients