Year-end Sale % OFF 
Abstract
This study was dedicated to detecting the effects of cadmium chloride and of cortisone on experimental infection with Toxoplasma gondii in rats through studying brain tissue. Twenty-four adult albino male rats were used, divided into four groups, comprising: untreated control as group 1, group 2: infected with intraperitoneal injection of Toxoplasma gondii 80 tissue cysts per animal, group 3: infected with Toxoplasma gondii and treated with intraperitoneal injection of cadmium chloride 1.5mg/kg once a week, group 4: infected with Toxoplasma gondii and treated with intramuscular injection of hydrocortisone in a dose 0.5 mg/kg once a week. After 30 days of treatment for all groups, the animals were sacrificed, and the gross and histopathological examinations were performed on the brains of the rats. The results revealed the presence of changes in the infected groups including appearance of toxoplasma tissue cysts in the grey matter, with mild to moderate perineuronal and periaxonal edema. There were further changes observed in infected groups which treated with cadmium chloride including perineuronal satelletosis, perineuronal edema and demyelination in neuronal axons, otherwise the infected groups treated with cortisone did not show any noticeable difference from the group of infection only. It is concluded that cadmium increase the intensity of occurrence of lesions induced by Toxoplasma gondii in the brain tissue of the rats, considering that all noticeable lesions ranged from mild to moderate in severity, and the differences between groups may be related to the nature of the pathogen used.
Highlights
Toxoplasmosis is zoonotic parasitic disease [1,2] can be considered as one of the most universally distributed infectious diseases [3]
The results revealed the presence of changes in the infected groups including appearance of toxoplasma tissue cysts in the grey matter, with mild to moderate perineuronal and periaxonal edema
It is concluded that cadmium increase the intensity of occurrence of lesions induced by Toxoplasma gondii in the brain tissue of the rats, considering that all noticeable lesions ranged from mild to moderate in severity, and the differences between groups may be related to the nature of the pathogen used
Summary
Toxoplasmosis is zoonotic parasitic disease [1,2] can be considered as one of the most universally distributed infectious diseases [3]. The infection is caused by Toxoplasma gondii, which is a protozoal parasite from the order: Sporozoasida, family: Sarcocystiidae, genus: Toxoplasma [4]. This parasite can invade several mammalian tissues [5,6], as well as avian tissues like in local poultry industry [7] Toxoplasma tissue cysts can develop in lungs, liver and kidneys but is most commonly noticed in nervous and muscular tissues, including brain, eyes, skeletal muscles, and heart [8,9]. The goal of the study is to compare the pattern of Toxoplasma infection in the brain of rats, alone, and in combination with cadmium chloride exposure and under effect of cortisone drug to monitor the effects through histopathological point of view
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
