Abstract
Prion diseases in humans are closely linked to consumption of bovine meant or organs infected with abnormal prions. Bovine organs which are most prone to prion disorders such as the brain and the liver, kidney etc are considered in various traditional cuisines over the world. Meat or edible parts should be tested safe from prions before releasing it into the market. The detection of prions proteins in bovine meat and other organs is a challenging task. The renowned methods include Quartz Crystal Microbalance and Surface Plasmon Resonance techniques. This paper narrates a performance analysis of the accuracy, sensitivity and feasibility of each technique over the other for the detection of abnormal prion protein. Successful detection of the infected prions will reduce the diseases related to abnormal prions in entering the food chain.
Highlights
Creutzfeldt–Jakob disease is the human form of Bovine Spongiform Encephalopathy
Amongst the different variations of Creutzfeldt-Jakob disease (CJD), variant CJD, is closely linked to the consumption of bovine meat contaminated with infected prions
Patent WO 2006/063437 the sensing layer was composed of PrP-C on the Thickness Shear Mode (TSM) and the response of the acoustic sensor resonance was observed after detecting PrP-Sc in a given tissue sample
Summary
Creutzfeldt–Jakob disease is the human form of Bovine Spongiform Encephalopathy. CJD is a neuro-degenerative disease caused by the misfolding of proteins. Misfolding of proteins, called prions, are the cause of the continuous death of neurons in the brain which eventually leads to the destruction of the brain and death of the host. Amongst the different variations of CJD, variant CJD, is closely linked to the consumption of bovine meat contaminated with infected prions. There were cases of variant CJD observed in both 2014 and 2013 according to the fact sheet [1]. The detection of prion proteins in meat or edible cow parts have become a prime research topic recently. This paper portraits the available techniques and their performance based on pion detection
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