Comparative study on histological changes around ulcer lesion and secretory function between peptic ulcer and ulcerative type of early cancer of the stomach

Abstract

Peptic ulcer and early cancer of the stomach possessing ulcer lesion of similar size locating near angular incisure were compared concerning histological changes around ulcer lesion and secretory function with the following conclusions. In peptic ulcer the restriction in the development of ulcer size is accompanied by the relatively stationary localized mucosal atrophic changes around ulcer lesion, while in gastric carcinoma the advancement of carcinomatous ulcer lesion brings the development of mucosal atrophic changes around lesion in degree and extent. Such findings may be interpreted as the evidence that some part of mucosal atrophie changes around ulcer lesion are secondary to ulcer lesion and the nature of ulcer lesion decides the future course of atrophie changes, although such histological changes proceed unevenly from direction to direction with marked individual variation. As to secretory function of the stomach no essential difference was found in maximal acid output (MAO) and pepsin output after maximal stimulation between two clinical entities. The correlation was recognized between the degree and the extent of mucosal atrophie changes and the degree of secretory disturbance in each individual case.