Abstract
The direct analysis of underivatized aminoglycoside antibiotics containing an aminoacyl group, butirosins, amikacin, and HAPA-B and its analogues, by desorption chemical ionization (D/CI) and molecular secondary ion mass spectrometry (SIMS) has been demonstrated. The general features and unique characteristics of these two methods are discussed. The [MH]+ ions in D/CI is not as strong as in molecular SIMS, however, the D/CI spectra provide straightforward sequence information. Comparative sequence specific fragments can be obtained in the metastable ion spectra of the [MH]+ produced by SIMS, and thus obtained sequence information often complements that with D/CI method. Combination of D/CI and molecular SIMS experiments has enabled the unequivocal characterization for the structures of aminoglycoside antibiotics containing an aminoacyl group.
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