Abstract
Objective: The development of myrrh extract from natural origin capable of eradicating schistosomal infection has gained the interest of many scientists. Recently, myrrh extract is considered as the drug of choice from natural origin used to treat schistosomiasis. This study was performed to evaluate the safety and efficacy of hard gelatin capsules of myrrh extract in the treatment of Schistosoma mansoni compared to Mirazid which is the only herbal drug present in the market.
 Methods: In the present study, the clinical evaluation of different doses of formulated myrrh extract hard gelatin capsules against different grades of S. mansoni infections (mild, moderate, and heavy) was carried out and compared with marketed soft gelatin capsules Mirazid.
 Results: In all types of S. mansoni infection, it was clear that the efficacy of n-hexane and alcohol myrrh extracts hard gelatin capsules was higher than or equal to that of Mirazid soft gelatin capsules.
 Conclusion: Hard gelatin capsules of myrrh extract (mixed doses) are more effective and more economic as a pharmaceutical dosage form for pharmaceutical manufacturers than Mirazid soft gelatin capsules. Consequently, with its lower price, it can reach the poor patient which is the main patient of schistosomiasis.
Highlights
Human schistosomiasis is a widely spreading tropical infection
Based on the latest reports, about 652 million people live in Africa at risk of infection and 193 million people are already infected with schistosomiasis [3]
Schistosoma mansoni infection is widely spreading in about 53 countries, especially in the Nile valley neighbors, Sudan and Egypt, as well as in the new world, including Brazil, Surinam, Venezuela, and seven islands in the Caribbean [2,3,4]
Summary
Human schistosomiasis is a widely spreading tropical infection. It causes complicated diseases with widely different symptoms [1]. In developing countries, it is considered as the second most prevalent disease after malaria that tremendously affects the social and economic development of these countries [2]. According to the previous studies, many patients are suffering from severe diseases as a result of their infection [4]. Schistosoma mansoni infection is widely spreading in about 53 countries, especially in the Nile valley neighbors, Sudan and Egypt, as well as in the new world, including Brazil, Surinam, Venezuela, and seven islands in the Caribbean [2,3,4]
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