Abstract
The present investigation deals with comparative study of beta chain of the enzyme tryptophan synthase from Salmonella typhimurium and Pyrococcus furiosus. The study yielded few significant results that the sequence of beta 2 subunit (PF1706) from Pfu is closely related to the beta chain of Salmonella typhimurium in comparison to the beta 1. The phylogenetics of these two strains indicates that the beta 2 subunit plays a vital role in tryptophan synthesis in Pyrococcus furiosus. In the present investigation Salmonella typhimurium was used as a reference organism for comparative genomics of tryptophan synthase beta chain amongst a group of organisms 13 archaea and 41 proteobacteria respectively. The study reveals that most of the sequences of archaea are distantly related and was observed that there are certain sequences like pfu PF1706 which are closer to Stm that is a proteobacteria.
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