Comparative study of transperitoneal laparoscopic radical prostatectomy and open radical prostatectomy

Abstract

Objective To compare the clinical efficacy and safety of transperitoneal laparoscopic radical prostatectomy (LRP) and open radical prostatectomy (ORP) for treatment of localized prostate cancer. Methods From March 2003 to December 2014, 395 consecutive cases of radical prostatectomy were retrospectively analyzed. The patients were divided into 2 groups: LRP group with 325 cases and ORP group with 70 cases. There were no significant differences in age (P=0.364), body mass index (P=0.360), preoperative PSA level (P=0.076), preoperative Gleason score (P=0.839) and prostate volume (P=0.241) between LRP group and ORP group. Therapeutic effect was compared between the 2 groups. Results The differences of operative time (LRP: 114±29 min, ORP: 150±39 min, P=0.002), blood loss (248±96, 569±166 ml, P<0.001), intestinal function recovery time (2.2±0.9, 3.0±0.8 d, P=0.031), postoperative hospital stay (7.1±1.4, 8.9±1.6 d, P=0.028) and complication rate(P<0.001) were significantly between the 2 groups. There were no significant differences in positive surgical margin rate(P=0.397) and 1–year or 2–year biochemical recurrence rate (P=0.664, P=0.238) between the 2 groups. Conclusion In the present cohort, compared with open surgery, LRP had advantages of fewer traumas, quicker recovery and fewer complications, while the tumor control was similar. Key words: Prostatic neoplasms; Laparoscopes; Radical prostatectomy; Open surgery; Treatment outcome