Abstract
This work was aimed at evaluating the effects of C. anomala and C. arabica on Methotrexate (MTX) induced metabolic disorders. For this, the aqueous extract (AE) of C. anomala and C. arabica were prepared and their polyphenols, flavonoids and alkaloids contents determined as well as their antiradical and total antioxidant capacity. An animal experimentation using female rats was carried out for 14 days. Rats were divided into 6 groups; a negative control group receiving water; a positive control group receiving 12mg/Kg Bw of MTX; four tests groups receiving 12mg/Kg Bw of MTX and one of the extracts at a dose of 200mg/Kg Bw or 400mg/Kg Bw. At the end of the experiment, plasmas and hemolysates were prepared as well as liver and kidney homogenates for the evaluation of oxidative status (catalase, total protein and malondialdehyde (MDA)), liver toxicity (alanine amino transferase (ALT)) and renal toxicity (creatinine and urea) and lipid profile (triglycerides, total cholesterol and HDL-cholesterol). Weight gain in extract-treated rats was better with the C. anomala. Concerning oxidative status, MDA levels were generally lower in C. anomala-treated groups compared to C. arabica while catalase level was higher in C. anomala-treated rats. As for lipid profile, it is C. arabica that showed more or less better results. Both extracts led to an amelioration of toxicity markers compared to exclusive treatment with MTX. The results of this study suggest that C. anomala and C. arabica may reduce metabolic disorders associated with the intake of MTX during cancer treatment; C. anomala protecting better C. arabica.
Highlights
Caffeine is responsible for the stimulatory power of coffee and kola nut
The results of this study suggest that C. anomala and C. arabica may reduce metabolic disorders associated with the intake of MTX during cancer treatment; C. anomala protecting better C. arabica
This study revealed the presence of phenolic compounds, flavonoids and alkaloids in the aqueous extracts of C. anomala and C. arabica (Table 1)
Summary
Caffeine is responsible for the stimulatory power of coffee and kola nut. The seeds of these two plants are highly consumed for this property. Some researchers have proven that the consumption of too much caffeine could affect the risk of developing cancer through various mechanisms. Other studies have shown the reduced risk of cancer with the consumption of coffee. The consumption of 3 to 4 cups of coffee per day is thought to reduce by 50% the risk of breast cancer in menopaused women and by 60% the risk of ovarian cancer. While for prostate cancer, this consumption could rather increase the risk of cancer development (Nehlig, 2012)
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