Abstract

Iron-dextran complexes (IDC) are well known models of the iron storage protein ferritin which are used or elaborated for treatment of iron deficiency anemia. IDC consist of the iron core in the form of FeOOH surrounding with the dextran shell. In the present study we compare the iron state in various IDC including commercial and elaborated samples using Mossbauer spectroscopy. We analyzed IDC from different sources such as Imferon (Benger, USA), Imferon (Fisons, UK), Ferridextran (Leciva, CSSR), Dextrafer (USSR) and elaborated complexes named as IDC26, IDC81, IDC87, IDC3P, IDC4P, IDC6P, IDC8P. These complexes were studied in lyophilized form and solution. Mossbauer spectra of IDC were measured using the high precision spectrometer at 297 K and 87 K for lyophilized IDC and at 87 K for IDC in solution.

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