Abstract
Study of the time course of protein synthesis by intact liver and brain mitochondria in rats of different age exposed to thyroxin in physiological concentrations (10-8 M) and cytoplasmic thyroxin-binding protein (modulator of thyroxin effect — MDT4) showed that thyroxin did not influence protein synthesis in liver and brain mitochondria. On the other hand, MDT4 stimulated protein synthesis, this stimulation correlating with the age of rats. In brain cells MDT4 enhanced labeled leucin incorporation in the embryonal and early postnatal periods. MDT4 is proposed to be involved in the mechanism of tissue-specific effect of thyroxin and in the formation of age-specific sensitivity to it.
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