Comparative study of the effects of fructose-1,6-diphosphate, fructose and physiological saline on the blood levels of glucose and adenosine-triphosphate after an oral glucose load

Abstract

After an oral glucose load, 30 healthy volunteers were injected intravenously with 1) physiological saline, 2) fructose-1,6-diphosphate sodium salt (FDP) and 3) an equimolar amount of fructose, in three different days. The sequence of the injections was random. In each treatment blood samples were collected before the glucose load and 15, 30, 45, and 60 min later. Adenosine triphosphate (ATP) and glucose levels were determined in each blood sample, which had been labelled according to a fixed code. The data were analyzed in two different biostatistical centers. In comparison with the levels found after physiological saline infusion, FDP significantly increased blood ATP, while fructose lowered it. Blood glucose level after fructose or saline infusion was the same, while after FDP infusion it was significantly lower.