Abstract
Objective: The objective of the study is to compare the effect of superoxide solution (SOD) and chlorhexidine gluconate on wound healing. Methods: Hundred patients with different types of wounds were recruited in this study and randomized to two groups: Group A- SOD group and Group B- Chlorhexidine group. Observations were made regarding type of wounds, reduction of edema, culture of wounds, improvement, cure rates, and hospital stay. Results: Although there were no significant difference in the reduction of edema and swelling of wound in both groups, the cure rates were statistically better with SOD (p=0.001) and hospital stay was also less with the use of SOD (p=0.006). Conclusion: SOD treated case showed less morbidity, with more improvement, and more cure rate compared to chlorhexidine solution with statistically significant p-value. However, further research into the use of SOD and the cytotoxic nature of chlorhexidine in the treatment of various wounds is required.
Highlights
Wound healing is affected by various growth factors such as epidermal growth factor, Interleukins, tumor necrosis factor, and platelet derived growth factor [1]
There has always been a search for an ideal antiseptic that is rapidly lethal to all forms of bacteria and their spores and capable of bactericidal properties for a prolonged period with no ill effect on host tissues
Chlorhexidine gluconate is an antiseptic thought to be effective against a wide range of Gram-positive and Gram-negative bacteria, yeasts, and some viruses [6]
Summary
Wound healing is affected by various growth factors such as epidermal growth factor, Interleukins, tumor necrosis factor, and platelet derived growth factor [1] In addition to, these there are various factors that influence wound healing such as age, nutritional, obesity, diabetes, immunosuppressants, and infections. Superoxidized solutions have shown to be both safe and efficient as a wound care product that moistens, lubricates, debrides, and reduces the microbial load of various types of lesions [2,3]. Another antiseptic is chlorhexidine, which is characterized as being a strong base with cationic properties. Chlorhexidine gluconate (aqueous or alcoholic) is an antiseptic thought to be effective against a wide range of Gram-positive and Gram-negative bacteria, yeasts, and some viruses [6]
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