Comparative Study of the Cytotoxicity of 70% Ethanolic Extracts of Pitadeniastrum africanum Hook (Fabaceae) and Hunteria eburnea Pichon (Apocynaceae) on HFF Cells (Human Foreskin Fibroblasts)

Abstract

Piptadeniastrum africanum and Hunteria eburnea are two plants that are recurrently mentioned in the treatment of several skin diseases in the Upper Sassandra Region. In order to better understand the mode of action of these two plants on skin cells, a comparative study of the cytotoxicity of ethanolic extracts in vitro was performed on HFF (Human Foreskin Fibroblasts) cells. The Mosman method was used to evaluate the cytotoxic activity of the ethanolic extracts of both plants. The cytotoxicity test performed in vitro on HFF cells revealed not cytotoxic effects of both plants on human cells at concentrations of 125 to 1000 ?g / mL. The different viability rates of the two ethanolic extracts were strictly greater than 30%. All these results demonstrate a safety of use of these two plants in the traditional treatment of various skin diseases.