Abstract
Introduction: Plants have always been a very good source of drugs. Diabetes mellitus (DM) is one of the common metabolic disorders acquiring around 2.8% of the world’s population. Hence in the present study, we intend to evaluate the antidiabetic property of the Teramnus labialis, Xanthium strumarium. Materials and Methods: T. labialis, Methyl extract Teramnus labialis (METL) and X. strumarium Methyl extract Xanthium strumarium (MEXS) were collected from hills of Tirupathi, dried, and powdered. Healthy male Wistar albino rats induced DM with the Streptozotocin-Nicotinamide and Alloxan induced model were studied on days 1, 7, 14, 21, 28 for the serum glucose (SG), total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein levels. The observations were compared with the standard drugs Glibenclamide. Results: When extracts administered at low dose in combination exhibited a valuable synergistic activity on mean blood glucose levels, which were almost similar when these results compared with that of standard drug-treated animals. Conclusion: Both the plant extracts were safe in the combination and do not shown any toxicities or drug-related interactions but future pharmacokinetic studies required to validate the given result.
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