Comparative study of short-term and long-term clinical outcome of modified radical mastectomy and breast conserving surgery in treating early staging breast cancer

Abstract

Objective To compare the short-term and long-term clinical outcome of modified radical mastectomy and breast conserving surgery in treating early staging breast cancer. Methods 134 patients with early staging breast cancer were enrolled into this study, including radical group and breast conserving group by using random number table method. Clinical data were analyzed by using statistical software SPSS 19.0. Measurement data such as perioperative indicators and life quality score were expressed as mean±standard deviation, and independent t test was used for comparison between the groups. Count data, such as 1 year-, 3 year-OS/DFS and postoperative complication rate were examined by using χ2 and log-rank test (α=0.05). A P value <0.05 was considered as statistically significant difference. Results The average blood loss in the radical group was lower than that in the breast conserving group, and the operation time and the average postoperative hospital stay were less than those in the breast conserving group, the scores of physiological function and mental health in the radical group were lower than those in the breast conserving group, with significant differences (P<0.05); the 3-year disease-free survival rate and the 3-year overall survival rate in the radical group were higher than those in the breast conserving group, with significant differences (P<0.05); the axillary lymph node metastasis rate in the radical group was lower than that in the breast conserving group, with significant difference (P<0.05). Conclusion The short-term and long-term clinical outcome of modified radical mastectomy for breast cancer patients are better than breast conserving surgery, the axillary lymph node metastasis rate is lower than the breast conserving surgery. It is safer and more effective and worth of clinical promotion. Key words: Breast neoplasms; Mastectomy, modified radical; Mastectomy, segmental; Comparative effectiveness research