Abstract
A comparative study of the efficacy of sterility testing of pharmaceuticals according to two systems is described. The culture media used in the first system were: dithionite—thioglycollate (HS-T) both, recommended by the Nordic Pharmacopoeia Board, and a peptone liver digest medium or a peptone liver digest agar. The media used in the second system were: fluid thioglycollate medium and soybean—casein digest medium, both prescribed by the USP XVIII, and Sabouranud liquid medium or Sabouraud dextrose agar. The supplemental use of one of the two latter media has been recommended, because the USP XVIII media were considered inadequate. A total of 180 cultures of fastidious bacteria. Yeats, and molds was investigated. The first system was found superior to the second.
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