Comparative Study of Prolactin Levels in Acne and Non-Acne Individuals among Adolescent

Abstract

Background: One of the most prevalent dermatological conditions affecting adolescents is acne vulgaris. The production of acne vulgaris lesions is a result of hormonal imbalances that impact skin conditions. Prolactin (PRL) is widely known for its involvement in the formation and operation of the mammary glands in addition to its more than three hundred non-lactational activities. Objective: This study aimed to evaluate and compare prolactin levels in serum hormone between persons with acne vulgaris and those without acne. Materials and Methods: In this cross-sectional case control study, serum levels of prolactin were collected and estimated in 80 subjects consisting of 40 males and 40 females each; of which 20 were the control group and 20, the test group in each category respectively. Also, certain criteria’s were looked into such as subject’s age, state of health, menstrual patterns (for females) and much more. Data collected was analyzed using the Software Package for Social Sciences (SPSS). At the end of the experiment, the result showed no significant change (p<0.05). Result: In both male and female adolescents, the mean serum prolactin level of those with acne was higher than that of those without the condition. In adolescents with acne, the mean serum prolactin level was higher (19.48 ± 11.04) than in those without acne (13.48 ± 5.22). P less than 0.05 indicated statistical significance. Conclusion: An increase in the mean serum prolactin levels of acne subjects in both categories when compared to non-acne subjects indicates the contribution of prolactin in the pathogenesis of acne.