Abstract
BackgroundOur goal was to compare the metabolic curves of plasma clearance of iohexol (ClIOH) at standard dose (5 ml) and contrast-level dose (50 ml). MethodsThe concentration of iohexol was measured at fasting state and at nine different time periods after a single bolus of iohexol injection. The interval between the injection of the two doses was longer than 24 hrs. Using a multi-point method and a dual-sample method, ClIOH-M and ClIOH-D were calculated, and the correlation and consistency of ClIOH between the two doses were compared. ResultsThe metabolic curves of iohexol at the 5 ml and 50 ml injection were substantially identical. The correlation of ClIOH-M between the two doses was 0.930, the mean deviation was 1.3 ± 6.9 ml/min/1.73 m2. Taking ClIOH-5ml-M as the standard, the ClIOH-50ml-D at 2 h and 4 h had a correlation coefficient of 0.975, a mean deviation of 0.1 ± 5.3 ml/min/1.73 m2, and the concordances were 100% corresponding to P30, 88.9% corresponding to P10, and 77.8% corresponding to P5. ConclusionWhen a regular dose of iohexol is used for enhanced CT, ClIOH can be used for the measurement of GFR, and a proper time for blood collection can be 2 h and 4 h.
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