Comparative study of plasma clearance of iohexol at different injection doses

Abstract

BackgroundOur goal was to compare the metabolic curves of plasma clearance of iohexol (ClIOH) at standard dose (5 ml) and contrast-level dose (50 ml). MethodsThe concentration of iohexol was measured at fasting state and at nine different time periods after a single bolus of iohexol injection. The interval between the injection of the two doses was longer than 24 hrs. Using a multi-point method and a dual-sample method, ClIOH-M and ClIOH-D were calculated, and the correlation and consistency of ClIOH between the two doses were compared. ResultsThe metabolic curves of iohexol at the 5 ml and 50 ml injection were substantially identical. The correlation of ClIOH-M between the two doses was 0.930, the mean deviation was 1.3 ± 6.9 ml/min/1.73 m2. Taking ClIOH-5ml-M as the standard, the ClIOH-50ml-D at 2 h and 4 h had a correlation coefficient of 0.975, a mean deviation of 0.1 ± 5.3 ml/min/1.73 m2, and the concordances were 100% corresponding to P30, 88.9% corresponding to P10, and 77.8% corresponding to P5. ConclusionWhen a regular dose of iohexol is used for enhanced CT, ClIOH can be used for the measurement of GFR, and a proper time for blood collection can be 2 h and 4 h.