COMPARATIVE STUDY OF PHYSIC-CHEMICAL PROPERTIES OF POLYSACCHARIDES SELECTED FROM PRUNELLA SPP.

Abstract

Natural high molecular weight compounds are used in medicine separately and in complex drugs as concomitant substance and as transport substances for the main compounds. Polysaccharides are plant polymers and its physic-chemical properties are useful in the development of pharmaceutical substances of plant origin. The aim of this study is investigation of physic-chemical properties of polysaccharides selected from Prunella spp. herb. For this aim, we solved the following tasks: estimate medium molecular weight of water-soluble polysaccharides (WSPS) and pectinic substances (PS) by viscosimeter, isoelectric point, distribution coefficient, superficial activity. Results. WSPS and PS from P. laciniata herb has the largest molecular weight (30493 g/mol and 25607 g/mol respectively). Macromolecules of WSPS and PS are electroneutral in the solution with pH<7. The molecules do not affect the surface tension at the boundary of the two phases, but at the same time they have a penetrating ability. Conclusions. Polysaccharides from Prunella spp. Have a high molecular weight more 10 k g/mol and this property may cause the elasticity of the dosage form. Macromolecules are electroneutral in the acidic environment and insoluble in water solution and have small ability to swell. Polymers have high penetrating ability through the cell membrane. These properties determine transport and bioavailability of polysaccharides and main compounds.