Abstract
Vaginal candidiasis is a common condition and up to 75% of women suffer at least one episode of this infection during their life time. Candida albicans is the most important cause of this, accounting for over 80% of the infections.Curcumin is a phytochemical, a component of folklore medicine since ages. Ithas been investigated as anti-inflammatory, anticancer, antimicrobial, and antifungal.Mucoadhesion has been propose for a variety of local as well as systemic purposes. Systems like tablets, films, gels, liquids and multiparticulates have been employed successfully. The objective of the present work was to formulate mucoadhesive vaginal film and tablet of Curcumin for the treatment of vaginal candidiasis is, and compare their performance. Film was cast by solvent evaporation method while tablet was prepared by direct compression. Both formulations were designed by using Xanthan gum and HPMC K15M. Evaluation and comparison was accomplished through parameters like mucoadhesion, drug release and zone of inhibition. Mucoadhesive strength of film was better at0.37mJ.Drug release found was 90-95% for film while 80-85% for tablet in 12 h.Antimicrobial study of film showed better performance than tablet against Candida albicans. The study reflected mucoadhesive curcumin films would be a better choice than tablets for vaginal candidiasis.
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