Comparative Study of Liver Function and Rh Blood Group between both Physiological and Pathological Neonatal Jaundice

Ali F Hassan,Ayia N Kamal

doi:10.31351/vol30iss1pp101-109

Abstract

Abstract Backgrounds: Jaundice occurs in most newborn due to increased bilirubin concentration. Jaundice is observed during the first week after birth in approximately 60% of term neonates. A high level of bilirubin is neurotoxic and may cause neonatal kernicterus, auditory neuropathy or death. Objectives: to compare the Rh group compatibility, serum bilirubin (total and direct), serum albumin and several liver enzymes between physiological and pathological neonatal jaundice Materials and Methods: A cross sectional study for one hundred neonates with jaundice divided into group 1: 50 newborns with physiological jaundice, Group 2: 50 newborns with pathological jaundice. Blood samples taken from each patient use to determination of Rh Group and blood group, serum bilirubin (total and direct, liver enzymes and albumin concentration. Results: in the present study Rh Compatibility show a significant relationship between newborns with physiological and pathological jaundice (p<0.05). Serum bilirubin (total and direct), serum albumin concentration and several liver enzymes were significantly higher when compare newborns with pathological jaundice with newborns of physiological jaundice (p<0.05). Conclusion: these finding demonstrate that newborns with pathological jaundice have higher concentrations of these parameters as compared with physiological jaundice .

Highlights

Jaundice is an elevated level of the pigment bilirubin in the blood, causing yellow discoloration of the body tissue resulting from the accumulation of an excess of bilirubin in skin [1]
These findings demonstrate that the newborns with pathological jaundice have significantly higher levels of the studied parameters (Serum bilirubin, albumin and several liver enzymes) in comparison with those with physiological jaundice
Blood sampling Blood sample (1 ml) taken from each patient and put in to serum separator tube centrifuged to isolate the serum which used for measurements of direct serum bilirubin, liver function test (ALT, Aspartate transaminase (AST) and Alkaline phosphatase (ALP)) and albumin concentration. liver function test (ALT, AST and ALP) and albumin concentration done in private laboratory other tests achieved in hospital laboratory

Summary

Introduction

Jaundice (hyperbilirubinemia) is an elevated level of the pigment bilirubin in the blood, causing yellow discoloration of the body tissue resulting from the accumulation of an excess of bilirubin in skin [1]. The bilirubin produced is transported to the liver in the conjugated form with plasma albumin. Bilirubin conjugation occur in the liver by UDP-. Greatly of the conjugated bilirubin in the gut is decomposed back to unconjugated bilirubin by the action of the enzyme betaglucuronidase that is present in the intestinal mucosa. The reabsorptions of unbound bilirubin into the blood stream take place by the action of enterohepatic circulation, this leads more of bilirubin load to the already overloaded liver [5].Severe hyperbilirubinemia (more than 20 mg/dL)

Methods

Results

Discussion

Conclusion