Abstract
Objective: Chronic Kidney Disease (CKD) is a silent epidemic of the 21st century. Cardiovascular disease (CVD) is a major cause of morbidity and mortality among patients with CKD. This study aims to evaluate the type of dyslipidemia in CKD patients and correlates with the severity of renal dysfunction in CKD patients.
 Methods: The observational study was conducted in the Department of General Medicine, PRM MCH, Baripada between May 2018 and January 2019. 262 patients of CKD above 15 y of age, satisfying the inclusion and exclusion criteria were included in the study.
 Results: Out of 262 patients, 64.50% (169) were male and 35.50% (93) were females with M: F of 1.8:1. The age range was from 20 to 95. The average age of the patients in the study was 56.66+12.22 y. 45.04 % (118) of the patients were between 46 and 60 y of age. 68.70% of the patients had dyslipidemia. The comparison between lipid profiles of cases and controls showed a significant increase in total cholesterol, triglyceride, LDL and decrease in HDL.
 Conclusion: The prevalence of dyslipidemia in non-diabetic CKD is high. A high degree of abnormality is found in HDL with disease progression, which is statistically significant. Therefore, maintenance of desired lipid levels either through diet or early initiation of lipid-lowering drugs can be helpful in decreasing the risk of cardiovascular complications in CKD patients.
Highlights
Chronic kidney disease (CKD) encompasses a spectrum of different pathophysiologic processes associated with abnormal kidney function and a progressive decline in glomerular filtration rate (GFR) [1]
There is an extremely significant fall in high density lipoprotein (HDL) (p
The results of the present study provide valuable information and an association between lipid abnormalities and CKD patients, concluding that the prevalence of dyslipidemia in non-diabetic CKD is high enough to pose a major health problem and this problem of dyslipidemia increases with the severity of CKD
Summary
Chronic kidney disease (CKD) encompasses a spectrum of different pathophysiologic processes associated with abnormal kidney function and a progressive decline in glomerular filtration rate (GFR) [1]. CKD is a clinical syndrome due to irreversible kidney dysfunction leading to excretory, metabolic and synthetic failure culminating into the accumulation of non-protein nitrogenous substances and presenting with various clinical manifestations [2]. Chronic Kidney Disease (CKD) is a silent epidemic of the 21st century. Not confined to the developed countries only. CKD is the 12th cause of death and the 17th cause of disability, respectively [3]. Estimated from population data, about 6% of the adult populations in the US have CKD stage 1 and 2, and 4.5% have CKD stage 3 and 4 [1]
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