“Comparative Study of 'Intravaginal Misoprostol Alone' Versus 'Extra Amniotic Ethacridine Lactate Instillation Followed by Intravaginal Misoprostol' for Mid Trimester (13-20 Weeks) Termination of Pregnancy”

Abstract

Objective(s): To compare the efficacy, safety and induction-abortion interval of alone versus Ethacridine lactate 0.1% followed by intravaginal Misoprostol for mid-trimester (13-20 weeks) abortion. Method(s): 60 women undergoing mid-trimester abortion were recruited for comperative study.They were devided into 2 groups. Group-A (30 cases) received intravaginal tab 600 g followed by 400 g 8 hourly and Group-B (30 cases) received extra-amniotic Ethacridine lactate 0.1% followed 6 hours later by intravaginal 400 g 3 hourly until abortion occurred or upto 48 hours. Result(s): Mean induction-abortion interval in Group-A was 24.9  10.83 hours whereas 18.3  6.1 hours in Group-B. In Group-A complete abortion occurred in 70% cases and in Group-B 83.33%. Failure rate in GroupA was 6.67% while none in Group-B. Efficacy of abortion in Group-A was 93.33% while 100% in Group-B. Side effects and complications were more common in Group-A than Group-B. Conclusion(s) : Ethacridine-lactate followed by is definitely a better and effective method for midtrimester abortion rather than using alone. Keyword(s): Intravaginal Misoprostol, Extra-amniotic Ethacridine lactate, mid-trimester abortion