Abstract
Hydrogen bonding interactions in N-methylacetamide (NMA) and methyl acetate (MA) system were studied by a combined application of infrared spectroscopy, excess infrared spectroscopy, and quantum chemical calculation. The ethyl formate (EF) and NMA system was also investigated as a comparison. The two systems show similar conclusions: The strength of hydrogen bonds was weakened during the dilution process. The aggregation of NMA break into oligomer and monomer, which interact with MA/EF, simultaneously. Continuous adding MA/EF, NMA oligomer transform into monomers, and they exist in the form of NMA−MA/EF complexes. Besides, some differences were existed in the two systems. The hydrogen bonds in NMA−MA system are stronger than those in NMA−EF system. Comparing the excess spectra of the two systems, more oligomers In NMA−MA system transform into NMA−MA complexes at the same concentration. Though MA/EF can form cooperative hydrogen bonds, the cooperativity is weaker than that in NMA self-aggregation. This work not only show the hydrogen bonds in NMA−MA/EF system but also provide information about the differences between ester CO and amide I. It is benefit to understand the changes of inserting an ester CO in protein.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
