Abstract
Hydrogen bonding interactions in N-methylacetamide (NMA) and methyl acetate (MA) system were studied by a combined application of infrared spectroscopy, excess infrared spectroscopy, and quantum chemical calculation. The ethyl formate (EF) and NMA system was also investigated as a comparison. The two systems show similar conclusions: The strength of hydrogen bonds was weakened during the dilution process. The aggregation of NMA break into oligomer and monomer, which interact with MA/EF, simultaneously. Continuous adding MA/EF, NMA oligomer transform into monomers, and they exist in the form of NMA−MA/EF complexes. Besides, some differences were existed in the two systems. The hydrogen bonds in NMA−MA system are stronger than those in NMA−EF system. Comparing the excess spectra of the two systems, more oligomers In NMA−MA system transform into NMA−MA complexes at the same concentration. Though MA/EF can form cooperative hydrogen bonds, the cooperativity is weaker than that in NMA self-aggregation. This work not only show the hydrogen bonds in NMA−MA/EF system but also provide information about the differences between ester CO and amide I. It is benefit to understand the changes of inserting an ester CO in protein.
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