Abstract
This study was designed to compare the hepatic and renal markers in treatment with two most commonly used drugs I.V. Amphotericin B and oral Miltefosine in diagnosed cases of KALA-AZAR. This was an ‘OBSERVATIONAL’ and ‘CROSS-SECTIONAL’ study. This study was conducted on two groups each had fifty patients. I.V. Amphotericin B and oral Miltefosine were given to group A and B respectively. Rise of serum bilirubin was not significant (p>0.05) in either group. Mean SGPT and SGOT level were more in group B than that of group A. But the rise in mean SGPT and SGOT level was not statistically significant (p>0.05). Rise in BUN was significant (p<0.01) by the 15th day in Group A patients but it did not cross the normal limit. There was not significant (p 0.05) rise in the mean serum creatinine level during treatment in patients of both groups.
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