Abstract
Objectives and Study: With increasing prevalence of clarithromycin and metronidazole resistant H. pylori strains, eradication rates with triple therapy have fallen below 80% worldwide. Unlike that to clarithromycin or metronidazole, H.pylori resistance to amoxicillin(AMO) remains uncommon. AMO is also unique in that its bactericidal effect against H. pylori is time dependent (6-8 h after administration) and can be amplified by increasing the maximum intragastric pH(>6.5) using high-dose proton pump inhibitor( PPI) .High-dose dual therapy, of a PPI and …
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