COMPARATIVE STUDY OF FIBRINOGEN LEVEL IN NORMAL PREGNANCY, HYPERTENSIVE DISORDERS OF PREGNANCY AND INTRAUTERINE FOETAL DEATH.

Abstract

Introduction: Haemostatic failure as a result of Obstetric complication of hypertensive disorders of pregnancy and intrauterine foetal death is an important cause of maternal mortality and morbidity. The assessment of the coagulation parameters is important to diagnose the severity of the disease. To compare Aims and Objectives- serum brinogen in normal pregnancy and in hypertensive disorder of pregnancy and intrauterine foetal death. This study was conducte Materials and Methods: d in the department of Obstetrics and Gynaecology, RIMS, Ranchi during the period of April'16 to September'17. A total of 450 patients after 28 weeks of gestation were taken for the study. 150 were cases of hypertensive disorder of pregnancy and 150 were intrauterine foetal death. 150 patients were taken as control for the comparative analysis. The brinogen levels in present study decrea Results: sed signicantly in patients with hypertensive disorder of pregnancy and IUD. The mean value of brinogen in normal patient was 446.72±38.35 mg/dl, in patients with hypertensive disorder of pregnancy was 413.96±74.07 mg/dl and in patients with IUD was 360.07±95.23mg/dl. There was a signicant difference noted in routine blood parameters such as Haemoglobin, Platelets and Total Leucocyte count in study group. The coagulation prole was also found to be deranged in the study population. The maternal and perinatal outcome in PIH and IUD was worse than in control group. The Conclusion: estimation of plasma brinogen is helpful not only in the early diagnosis of haemostatic failure but also to guide replacement therapy during the brinogen depletive state.