Comparative Study of Ferromagnetic and Superparamagnetic Iron Oxide Nanoparticles Loaded with Antitumor Drug Doxorubicin

Abstract

In this paper we have studied the physical properties of magnetic nanocomplexes (MNCs) consisting of ferromagnetic iron oxide nanoparticles (FMION) or superparamagnetic iron oxide nanoparticles (SPION) loaded with antitumor drug doxorubicin (DOXO). The methods of magnetometry, electron paramagnetic resonance spectra, and absorption spectroscopy were used. The changes of electromagnetic waves from SPION and FMION under the influence of constant magnetic field (CMF) were analyzed. It was observed that MNC containing SPION and DOXO has larger coercivity as compared to MNC of FMION and DOXO. MNC comprising of SPION and DOXO has g-factors of 2.00, 2.30, and 4.00. MNC of FMION and DOXO has the g-factor of 2.50, and the integrated intensity of electron spin resonance signal is higher. MNC containing SPION and DOXO has absorption maximum shifts in the region (465–480) nm. MNC of FMION and DOXO has the absorption maximum in the range of (390–430) nm. On average the intensity of an alternating magnetic field (AMF) at different values of CMF is higher when SPION is used than FMION. The results presented here along with our earlier biological results open up promising prospects for future studies of cancer magnetic nanotherapy using MNC of SPION and DOXO.