Comparative study of enodonasal endoscopic surgery vs. microsurgery for pituitary adenoma

Abstract

Objective To study the enodonasal endoscopic surgery and microsurgery for the treatment of pituitary adenoma. Methods Following the randomized controlled experiment method, the patients were randomly divided into two groups. Forty cases of pituitary adenoma underwent the endoscopic enodonasal transsphenoidal surgery, and in the same period,40 cases of pituitary adenoma underwent the microscopic enodonasal transsphenoidal surgery. The physical data, clinical manifestation, imaging examination, endocrine examination before surgery,bleeding vomume and CSF leak during the surgery,and the postoperative hospital stay, tumor total removal, the relief of clinical symptom, the recovery of hormone and complications were compared between two procedures. Results Endoscopic group was more excellent than microscopy group in bleeding volume,The former is(48.6±6.0)ml and the latter is(78.4±13.0)ml,CSF leak or not during the surgery(χ2= 13.131,P 0.05), the relief of clinical symptom(χ2= 4.310,P> 0.05), the recovery of hormone after operation(χ2= 8.342,P> 0.05),and the difference was not statistically significant. The complications after operation of Endoscopic group were much less than microscopy(χ2= 3.675,P<0.05), and the difference was statistically singificant. Conclusion The endoscopic endonasal transsphenoidal surgery is a safe and effective procedure. Key words: Hypophysoma; Neuroendoscopy; Endonasal transsphenoidal surgery