COMPARATIVE STUDY OF EFFICACY OF ONDANSETRON VERSUS ONDANSETRON AND DEXAMETHASONE COMBINATION IN PREVENTING POSTOPERATIVE NAUSEAAND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY

Abstract

This study aims to compare the efcacy of Ondansetron alone versus Combination of Ondansetron and Dexamethasone in terms of preventing Postoperative Nausea and Vomiting, Pain and duration of hospital stay. Material And Methods:Aprospective interventional randomized control study was conducted in the Department of General Surgery, SGT Medical College Hospital and Research Institute, Gurgaon, Haryana. The randomization was done according to the standard methods to allocate the patients to either Group A(total 30 patients) receiving Ondansetron 4mg + 2ml normal saline (total of 3ml) intravenous (IV), 1 minute before induction of anesthesia and Group B (total 30 patients) receiving Ondansetron 4mg and Dexamethasone 8mg (total of 3ml) IV, 1 minute before induction of anesthesia. Adequate sample size of 60 patient fullling inclusion and exclusion criteria mentioned are studied. The data was collected in a pre-designed study proforma and statistical analysis was performed. The treatment and drug efcacy were compared between two groups in terms of postoperative nausea and vomiting, pain and duration of hospital stay. RESULT: The total incidence of post-op nausea and vomiting following administration of Dexamethasone along with ondansetron was 1 patient (3.3 %) whereas 15 patients (50%) in group where dexamethasone was not administered which is signicant. The 1 patient of Group B was a case of abdominal tuberculosis with brosis of stomach serosa. Marked relief in post-op pain and shorter hospital stay was observed in group B which was administered steroid. Conclusion: From this study, we can conclude that administration of steroid like dexamethasone along with Ondansetron has signicant role in prevention of post-op nausea and vomiting, pain and gives shorter hospital stay, making it a necessary step to be followed when performing Day-care Laparoscopic Cholecystectomy.