Comparative Study of Efficacy of Jatamansi (Nardostachys jatamansi DC) and Imipramine in Generalized Anxiety Disorder (G.A.D.): A Randomized Controlled Double Blind Clinical Trial

Abstract

Background: Onset of G.A.D. is related with bigger excessiveness and uncontrolled worry, along with more chronic course and more severe life mutilation.Individuals suffering from G.A.D. are at high risk of bothered mental health, social functioning, and overall physical &mental well being. Limited long-term efficacy of anxiolytic drugs has shown by clinical trials but drowsiness, dependency, impaired cognition and memory and sexual dysfunction like loss of libido are common adverse side effects of these drugs. Nardostachys jatamansi is a reputed Ayurvedic herb useful for treatment of various disorders mainly central nervous disorders. Various preclinical and clinical studies had proven anxiolytic activity of Jatamansi. Hence present study is planned to assess effects of Jatamansiin Generalized Anxiety Disorder.
 Materials and Methods: Presentdouble-blind randomized control clinical study involves two groups with 38 subjects each. Group A (Study Group) will be treated with administration of Tab. Jatamansi in the dose of 1000 mg B.D. orally with water. Group B (Control Group)will betreated with administration of Tab. Imipramine 75 mg H.S. orallyfor 60 days. Assessment parameter will be anxiety score based on symptoms of Generalized Anxiety Disorder. H.A.M.-A. Scale, G.A.D. – 7 Scale, Manas Bhava and Oxidative Stress. Primary outcome of study is improvement in the sign and symptoms of anxiety with reduction in anxiety scale score.