Abstract
Effects of isoproterenol (Iso) and vasoactive intestinal polypeptide (VIP) on voltage-dependent Ca 2+ channel ( I Ca ) and Ca 2+-activated K + channel current ( I K- Ca ) in porcine tracheal smooth muscle cells were examined. When K + currents were inhibited using a Cs-rich pipette solution, application of 0.1–1 μM Iso or 1–10 nM VIP increased I Ca by 20–30%. On the other hand, I K- Ca elicited upon depolarization and spontaneous transient outward K+ currents (STOCs) recorded at a holding potential of -50 mV were enhanced by 80–100% in the presence of 0.1 μM Iso or 1 nM VIP.
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