Comparative study of core needle biopsy with excisional biopsy: To determine diagnostic accuracy & concordance with er/pr/her-2/neu status

Abstract

Background: As there is continuous and increased need for early detection of cancer in breast lesion is never-ending. It is so, as the success of treatment depends upon early diagnosis. So role of core needle biopsy (CNB) in screening and diagnosing the breast lesion was evaluated. Aims and Objectives: To find concordance between the diagnostic power of, hormonal receptors, viz. estrogen receptors (ER), progesterone receptors (PR) sensitivity along with expression of HER-2/neu in CNB and excisional biopsy (EB) of breast lesion. Materials and Methods: We have studied the diagnostic accuracy of CNB in 60 breast lesion keeping the EB as gold standard. Immunohistochemical study (IHC) was simultaneously performed with three parameters as ER, PR and HER-2/neu. The results IHC studies of CNB were compared with the same study on EB specimens. Results: Out of which 39 cases were malignant and amazingly CNB has detected the malignancy in 38 cases. Also the IHC of ER, PR and HER-2/neu were well in concordance with the same study in EB specimen. Conclusion: Though CNB is excellent modality for screening, as study reflects, it can surely be used for confirmation also. As IHC results on CNB are also in well concordance with EB, the oncologist can lay out his treatment from very initial step of screening. Keywords: Core needle biopsy (CNB), Excisional biopsy (EB), Estrogen receptor (ER), Progesterone receptor (PR) and HER-2/neu