Abstract
Introduction: Hepatitis can be defined as inflammation of the liver. Hepatitis may be acute or chronic. It is estimated that in 2017, approximately 15 million people suffered from Hepatitis in Pakistan suffering from hepatitis. 150–200 million people, or approximately ~3% of the world's population, are living with chronic Hepatitis C.
 Methodology: A descriptive cross-sectional study was conducted on 300 patients selected by purposive sampling who were reported with Hepatitis-C and co infection of Hepatitis-C + Hepatitis-B, at a tertiary care hospital Gambat. A series of questions were asked from reported patients regarding symptoms and compliance.
 Results: The results were analyzed by using SPSS-22. Among the 300 patients some were on sofosbuvir (n=150, 50%), which the others were on interferon (n=150, 50%). The findings showed that most of the patients on interferon were non-compliant (n=125,83.3%), and only (n=25, 16.7%) are compliant. Among non-compliant factors, fear from injection was reported in (n=42, 33.6), technique for injection (n=38, 30.4%), prolong duration of action (n=35, 28%), adverse drug reaction (n=26, 20.8%). Better compliance was observed with sofosbuvir (n=93, 62.8%) and non-compliant were (57, 38%).
 Conclusion: This study concluded that better compliance was achieved with sofosbuvir as compared to interferon, rate of ADR’S were also less with sofosbuvir.
Highlights
Hepatitis can be defined as inflammation of the liver
Was described, which shows that out of 150 patients 125 (83.3%) study subjects were non compliant with interferon where as 25 (16.7%) study subjects were compliant with interferon
This study shows that majority of study subjects were non-compliant with interferon
Summary
Hepatitis can be defined as inflammation of the liver. Hepatitis may be acute or chronic. 150–200 million people, or approximately ~3% of the world's population, are living with chronic Hepatitis C. The infection is often asymptomatic, but chronic infection can lead to scarring of the liver and to cirrhosis, which is generally apparent after many years [7] It can be transferred by intravenous administration of drugs, blood transfusion, Organ Transplant without HCV screening, Sexual/household exposure to antiHCV-positive contact etc. Compliance can be defined as the degree to which a patient correctly follows medical advice [10]. Most commonly, it refers to medication or drug compliance, but it can apply to other situations such as medical device use, self care, self-directed exercises, or therapy sessions [11]. All the factors that contribute to a patient’s experience using prescriptions are known as patient experience [16,17]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
