Comparative Study of Coagulation Profile in Normal Pregnant Women, Pregnant Women at High Risk, Normal Non-Pregnant Healthy Women and Pregnancy Outcome

Abstract

Aims and Objective: To study and compare coagulation profile in normal pregnancy, pregnant women at high risk, non-pregnant women and pregnancy outcome. Method: This comparative prospective study was done in tertiary healthy care centre of north India for over period of one year. Result: Total 230 cases were taken, out of which 222 antenatal cases were unbooked cases with no antenatal visits along with 8 non-pregnant healthy women. Cases were further divided into three groups of non-pregnant women, normal pregnant women and pregnant women at high risk. All groups were compared for derangement of coagulation profile and pregnancy outcome in terms of adversity. In normal pregnant women (Group-1), there were 2 cases (94.4%) of deranged coagulation with isolated thrombocytopenia. In pregnant women at high risk (Group-2), 31 cases (16.6%) were having deranged coagulation out of which maximum cases were of eclampsia- preeclampsia spectrum (eclampsia and HELLP syndrome) followed by anaemia, placental abruption and placenta previa. In terms of adverse pregnancy outcome, maximum mortality was again in ecalmpsia and HELLP syndrome cases. In adverse perinatal outcome along with eclampsia and HELLP syndrome, preterm labour and FGR was a significant factor. Conclusion: Hypertensive disorders of pregnancy remain the main cause of deranged coagulation and adverse outcome in high risk pregnancy group along with anaemia and liver disease.