Abstract
Comparative study of carboxylate and amide forms of HLDF-6 peptide: Neuroprotective and nootropic effects in animal models of ischemic stroke
Highlights
Cerebrovascular diseases are among the most urgent medical and social problems of the modern world
We describe the results of similar investigations in the animal model of ischaemic stroke (IS) - We focused on the study of cognitive functions to identify the most effective form and doses of the drug in order to further study the mechanisms of its action and possible therapeutic potential
The HLDF-6 peptide is a fragment of natural human leukaemia differentiation factor (HLDF) present in the blood and central nervous system of mammals and humans
Summary
Cerebrovascular diseases are among the most urgent medical and social problems of the modern world. One of the most severe cerebrovascular diseases is ischaemic stroke (IS). Mechanisms of brain tissue damage development under conditions of cerebral ischaemia necessitate the introduction of a special type of therapy known as neuroprotection. A tight interconnection between all mechanisms of nervous tissue death motivates exploitation of the modulating effect that could be achieved through stimulation of the regulatory systems. An optimal scenario of therapy for IS and other cerebral disorders should comprise the application of agents simultaneously affecting several key components in the pathogenesis of the disease. Another important requirement for these compounds is the absence of toxic effects when used for prolonged preventive treatment.
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