Comparative study of bisoprolol tablets and diltiazem sustained-release capsules treatment of coronary myocardial bridge

Abstract

Objective To investigate the clinical characteristics of coronary artery myocardial bridge and to compare the treatment effects by bisoprolol tablets and by diltiazem extended-release capsules. Methods A total of 43 patients with chest pain and diagnosed coronary myocardial bridge by coronary angiography were randomly divided into 2 groups: bisoprolol group (n=21, patients accepted bisoprolol tablet 5mg daily) and diltiazem group (n=22, patients were given diltiazem sustained release capsule 90 mg daily). Angina attacks per month and the results of exercise stress test were recorded before and after treatment, and compared between the two groups. Results The frequency and sustained time of angina attacks in both groups were significantly reduced after bisoprolol tablet or diltiazem sustained release capsule treatment, and exercise-induced angina time and ST segment depression time were improved in both groups (all P<0.05), especially in bisoprolol group (all P<0.05). Conclusions Both bisoprolol tablets and diltiazem sustained release capsules can effectively alleviate angina pectoris induced by coronary myocardial bridge and bisoprolol tablets seems more effective than diltiazem extended-release capsules. Key words: Myocardial bridging; Bisoprolol; Diltiazem