Comparative Study of Antimicrobial, Anti-Inflammatory, and Antioxidant Activities of Different Parts from Pterocarpus Santalinoides l'Her. Ex. DC (Fabaceae).

Aimé Cézaire Ayéna,Messanvi Gbeassor,Kossi Dosseh,Amegnona Agbonon,Kokou Anani,Talha Bin Emran

doi:10.1155/2021/8938534

Aimé Cézaire Ayéna, Messanvi Gbeassor + Show 4 more

Open Access

https://doi.org/10.1155/2021/8938534

Copy DOI

Abstract

Aims Pterocarpus santalinoides is used in Beninese folk medicine for treatment of gastroenteritis. This study aims to compare the antimicrobial, antioxidant, and anti-inflammatory activity of the hydroalcoholic extracts of the leaves, trunk bark, and root. Materials and Methods The antimicrobial activity was evaluated by the broth microdilution method on 06 bacterial strains including 03 wild-type strains (Escherichia. coli 0157H, Salmonella sp., and Staphylococcus aureus sp.) and 03 reference strains (E. coli ATCC 25922, S. aureus ATCC 29213, and Pseudomonas aeruginosa ATCC 27853), whereas the anti-inflammatory activity was performed by the carrageenan-induced paw edema method on rats. The DPPH-free radical scavenging was used to determine the antioxidant activity. Results The MICs of the leaf extracts varied from 6.25 to 25 mg/mL for all strains. The MICs of the stem bark extracts were 6.5 to 25 μg/mL for five strains (E. coli 0157H, S. aureus ATCC 25922, Salmonella sp., E. coli ATCC 25922, and P. aeruginosa ATCC 27853) and 3.125 mg/mL for S. aureus. Concerning the root extracts, the MICs varied from 12.5 to 50 mg/mL. The best anti-inflammatory power was obtained with the stem bark extract with the percentages of inhibition of 36.09%, 38.98%, and 39.50%. The DPPH test showed that the hydroethanolic extract of the 03 parts of P. santalinoides has a moderate antiradical power compared to the control which was quercetin. Conclusion In view of the different pharmacological activity recorded, the extract of the leaves should be recommended to treat patients suffering from gastroenteriditis.

Highlights

Medicinal plants have been used since ancient times as medicines for the treatment of human diseases [1]
Ese parts of P. santalinoides were collected in April-May 2014 in the commune of Adjarra in southern Benin. e identification followed by the certification was carried out by Professor Hounnankpon YEDOMONHAN, the curator of the National Herbarium of the University of AbomeyCalavi, under the reference number DGB_21
Irty minutes before the induction of plantar edema by injection of 0.1 mL of 1% carrageenan, four different doses (125, 250, 500, and 750 mg/kg) of each P. santalinoides extract were administered orally to different successive groups of five rats. e different doses were chosen based on the results of tests carried out on extracts of a species of the family that Pterocarpus erinaceus

Summary

Introduction

Medicinal plants have been used since ancient times as medicines for the treatment of human diseases [1]. E DPPH test showed that the hydroethanol extract of the parts (leaves, stem bark, and root) of P. santalinoides has moderate antiradical power compared to the control, which is quercetin (Table 2). E stem bark extracts showed variable MBCs against the studied strains with a value of 6.25 mg/mL for the reference strain of Staphylococcus (S. aureus ATCC 25922).

Results

Conclusion