Comparative study of antidiabetic effect of Abroma augusta and Syzygium cumini on alloxan induced diabetic rat

Abstract

Herbal formulations are getting more importance in the treatment of diabetes, cancer and hepatic disorder because of the hazardous adverse effects of the current therapy. Especially diabetes can be controlled by Allopathic medicine as well as Herbal medicine. This study would be helpful for the industry to produce herbal formulation with less side effects and cost effective treatment for diabetes. Moreover in vivo models were utilized to test the antidiabetic property and it will be useful for fix the optimized dose in herbal formulation. The findings of the bioactive molecule from the herbals would be effective drug target against the diabetes. A comparison was made between the antidiabetic activities of methanolic extracts of leaves of Abroma augusta and seeds of Syzygium cumini in alloxan induced diabetic rats. Serum glucose level, weight variation and other histopathological studies were conducted at the dose 300 mg/kg body weight for 7 days. There was a significant decrease in serum glucose level (p<0.001), increase in body weight and changes in normal cells was observed with treatment of the above mentioned extracts which altered in diabetic rats as compared to the standard.