Abstract
In this study beetroot and eggplant were used as natural source for production of anti-anemic functional food for anemic patients and to prevent it during disease or chemotherapy treatment. Anemic model was induced in albino female rats by daily injection with phenylhydrazin (5mg/kg b.w) for three successive days, then biochemical, hematological and histological parameters were determined including; iron, ferritin, Ascorbic acid, Hepicidin, Hemoglobin and Complete blood count (men corpuscle volume, men corpuscle hemoglobin, haematocriet, red blood cells and white blood cells). Negative control group of normal rats, and positive control group of anemic rats each of six rats were fed on basal diet. Also 24 anemic rats were divided into 4 groups each of 6 rats which were fed on basal diet containing either eggplant or beetroot in ratios of 100, 300g/kg, in addition to 500mg ascorbic acid and 2mg folic acid/ kg diet for all groups for 30 days. feeding period was 30 days. At the end of experiment the above biochemical and haematological parameters were evaluated and the liver and spleen were histopathological examined. Decreases in hemoglobin, men corpuscle volume, haematocriet, red blood cells, men corpuscle hemoglobin, iron, ascorbic acid and ferritin, also increases in white blood cells and hepcidin were observed in anemic model rats. At the end of feeding period with the previous supplemented tested basal diet, increases in all aforementioned parameters, except white blood cells and hepcidin which showed decreases compared to anemic positive group were found.
Highlights
Two billion people suffer from anemia worldwide and most of them have iron deficiency and hemolytic anemia due to toxicants and oxidants
The fresh beetroots and eggplant were chemically analyzed for their nutrients; protein. fiber, ash, iron, calcium, magnesium, ascorbic acid and folate
Phenylhydrazin was used for many years in the experiments for induction of anemia in animals, it induced anemia as a model for the study of haematinic effect; it decreases HB, red blood cell (RBC) and impairs erethocyte deformability, vit C is decreased in oxidative stress caused by PHZ in vitro [28]
Summary
Two billion people suffer from anemia worldwide and most of them have iron deficiency and hemolytic anemia due to toxicants and oxidants. Anemia is an important risk factor associated with the severity of illness of corona virus disease (covid-19), and healthcare should be sensitive to hemoglobin and iron levels of covid-19 on patients on admission [3]. The occurrence of cardiovascular and renal diseases with anemia is termed ‘cardio –renal – anemia syndrome’. It is caused by a relative shortage of erythropoietin and can be associated with disordered iron homeostasis caused by reduced iron absorption, occult blood loss and impaired iron mobilization [5], as well as chronic inflammation. Among the most important nutrients deficiency can lead to nutritional anemia are iron, folic acid, vitamin B6, vitamin B12, vitamin C and protein
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